Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS
نویسندگان
چکیده
منابع مشابه
Deep gray matter T2 hypointensity correlates with disability in a murine model of MS.
Advanced MRI studies demonstrated several diffuse non-lesional features in multiple sclerosis, including changes detectable in gray matter areas. Standard T2 weighted MRI scans of deep gray matter structures, including the thalamus, caudate, putamen, dentate nuclei often demonstrate hypointensity. T2 hypointensity has been shown to correlate with cognitive, neuropsychiatric and motor dysfunctio...
متن کاملGray matter SWI-filtered phase and atrophy are linked to disability in MS.
The association between clinical outcomes and abnormal susceptibility-weighted imaging (SWI)-filtered phase, indicative of increased iron content, as well as atrophy, was investigated in the subcortical deep-gray matter (SDGM) of multiple sclerosis (MS) patients. 149 relapsing-remitting (RR) and 61 secondary-progressive (SP) MS patients underwent SWI on a 3T scanner. Mean phase of the abnormal ...
متن کاملGray Matter Atrophy Associated With Motor Dysfunction
34 Courtney Oare is a 2017 graduate of Purdue University who majored in Radiological Health Sciences with a concentration in Medical Physics. In the School of Health Sciences Honors Program, she partook in research for three years with an interest in imaging and evaluation of disease. Outside of coursework and research, she served as an Ambassador for the College of Health and Human Sciences, w...
متن کاملGray Matter Atrophy Associated With Motor Dysfunction
34 Courtney Oare is a 2017 graduate of Purdue University who majored in Radiological Health Sciences with a concentration in Medical Physics. In the School of Health Sciences Honors Program, she partook in research for three years with an interest in imaging and evaluation of disease. Outside of coursework and research, she served as an Ambassador for the College of Health and Human Sciences, w...
متن کاملRevisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis
BACKGROUND Brain atrophy is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment. METHODOLOGY/PRINCIPAL FINDINGS Based on MRI scans of 60 MS cases and 37 healthy volunteers, we measured the volumes of white matter (WM) lesions, cortical gray matter (GM), cerebral WM, caudate nucleus, putamen, thalamus, ve...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2009
ISSN: 0022-510X
DOI: 10.1016/j.jns.2008.11.018